These articles highlight emerging research and clinical insights into how disruptions in the microbiome may contribute to recurrent UTIs and chronic pelvic pain syndromes, with implications for diagnosis, treatment, and prevention.
This curated collection is guest edited by Harry Horsley, PhD and brings together leading experts and offers a multidimensional view of this timely topic. Current articles in the collection explore topics such as:
- Microbiologist in the Clinic: Antibiotic Dependent in her 30s. This article explores the case of a 32-year-old woman with persistent urinary symptoms and antibiotic dependence despite extensive testing and treatment. Clinicians and lab scientists discuss the complexities of her case and review evidence-based approaches for evaluation and management.
- A Cross Sectional Study of Cytokines in Women with Refractory Detrusor Overactivity versus Controls. This study found that women with refractory detrusor overactivity (DO) had elevated levels of pro-inflammatory urinary cytokines compared to controls, and these levels correlated with indicators of urinary tract infection (UTI). The findings suggest that underlying inflammation linked to UTIs may contribute to the development of refractory DO.
- Segmental Acupuncture for Prevention of Recurrent Urinary Tract Infections. A Randomised Clinical Trial. This randomized controlled trial found that segmental acupuncture, when combined with cranberry products, significantly reduced the number of UTIs and increased the proportion of UTI-free women over 12 months compared to cranberry alone. The results suggest acupuncture may be a promising long-term strategy for preventing recurrent UTIs in women.
- Therapeutic Effects of AF219 on Interstitial Cystitis/Bladder Pain Syndrome Induced by Cyclophosphamide or Water Avoidance Stress in Rats. This study found that AF219, a P2X3 receptor antagonist, significantly reduced pain behaviors, bladder inflammation, and overactivity in rat models of interstitial cystitis/bladder pain syndrome (IC/BPS). The results suggest that targeting P2X3 receptors may be a promising therapeutic strategy for IC/BPS.
Coming soon to this growing collection are articles exploring exciting and innovative research topics, including:
- Long-term Antibiotics for Disturbed Bladder Microbiome Disorders
- The Urinary, Vaginal, and Perineal Microbiome: Commonalities and Differences
- Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead
- Urinary Metabolomic Profile is Minimally Impacted by Common Storage Conditions and Additives
Together, these contributions explore how microbial ecosystems influence urogynecologic health and pave the way for new diagnostic and therapeutic strategies.
Interested in contributing to this special section? We welcome ongoing submissions related to the microbiome, UTIs, and bladder pain. Please contact the editorial office at
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